Início Singapura Research Fellow (Cancer Science Institute)

Início Singapura Research Fellow (Cancer Science Institute)

Research Fellow (Cancer Science Institute)

Full time na Duke-NUS Medical School no Singapore
Publicado em January 25, 2025

Detalhes do emprego

The ADJ Laboratory at Cancer Science Institute, focuses on understanding the immune system's recognition of cancer cells after DNA-damaging chemotherapy. The lab’s goal is to guide the rational design of immunotherapy-chemotherapy combinations for cancer treatment, with a particular emphasis on lymphomas and collaborations with the NUH Lymphoma team. The Research Fellow will play a pivotal role in advancing these efforts by conducting cutting-edge research at the intersection of molecular and cellular biology, immunology, and translational cancer therapy. Conduct Research: Investigate intracellular mechanisms in cancer cells influencing immune activation after DNA damage. Develop and evaluate combination strategies to enhance the efficacy of genotoxic chemotherapy using cell-intrinsic and cell-extrinsic approaches. Experimental Design and Execution: Utilize cell line models for epithelial and lymphoid cancers to study DNA repair and immune activation mechanisms. Design and perform in-vitro assays and systems to analyze immunogenic responses to chemotherapy. Perform quantitative microscopy on histological material to explore immune modulation pathways. Data Analysis and Dissemination: Analyze experimental results, interpret findings, and prepare research publications in high-impact journals. Present research outcomes at local and international conferences. Collaborations: Work closely with local and international collaborators for clinical sample acquisition and analysis. Partner with pharmaceutical and medical technology companies to facilitate clinical translation and biomarker development. Mentorship and Supervision: Provide guidance and mentorship to graduate students, post-doctoral researchers, elective students, and medical trainees involved in the lab’s projects. Research Development: Contribute to securing research funding through grant proposals and fostering academic-industry collaborations. #J-18808-Ljbffr

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