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Principal Scientist, Analytical Science and Technology

Full time at Vertex Pharmaceuticals in Online
Posted on March 30, 2024

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Principal Scientist, Analytical Science and Technology

Apply locations Boston, MA time type Full time posted on Posted 3 Days Ago job requisition id REQ-21605 Job Description Job Description Vertex is seeking a talented, experienced analytical chemist for late-stage product development in a commercial setting with an interest in Process Excellence. Working directly with our contract manufacturing organizations and a highly diverse group of scientists at Vertex you will solve complex problems encountered in commercial production/manufacturing of drug products. You will be part of an organization that thrives on innovation and is at the forefront of implementing Quality by Design and Continuous Manufacturing.  To be considered for this position the applicant will need to be a collaborative, experienced and competent analytical chemist with a history of developing, implementing and troubleshooting analytical methods in the pharmaceutical industry, with the ability to influence colleagues, and possessing strong communication and negotiation skills. Key Responsibilities
  • Method transfers for small molecule drug product to various CMOs or between internal groups
  • Method validation or co-validation to support late-phase and commercial projects
  • Authoring/reviewing documentation to support new and existing commercial products (methods, SOPs, transfer protocols/reports, lab notebooks, technical reports, etc.)
  • Independently managing CMOs for analytical services, leading analytical OOS/OOT investigations and assisting process investigations
  • Commercial data collection, interpretation, reviewing, trending, and report generation to support continuous process verification
  • Continuous method improvement through commercial change control procedures
  • Uses defined methodologies (e.g. RCA, Lean/Six Sigma, process mapping, analytics & overall application of DMAIC project framework) to identify, analyze, and implement sustainable process improvements
Knowledge and Skills:
  • Experience in an analytical development or technical operations role, supporting new product development and/or commercialization
  • Problem-solving/root cause analysis for analytical related issues
  • Experience with chromatography methods such as HPLC, GC, and other common analytical techniques used in pharmaceutical analysis
  • Experience with compendial methods for analysis (e.g. KF, elemental impurity testing, and identification by spectroscopy)
  • Knowledge of cGMP’s (e.g. Quality Control), ICH guidelines and associated CMC regulatory considerations in a pharmaceutical setting
  • Proficient with data analytics and visualization tools
  • Strong communication and technical writing skills
  • The ability to work successfully in both a team/matrix environment as well as independently
  • Demonstrated ability to effectively manage project(s), and flexibility to accommodate changes in responsibilities or project priorities
Education and Experience:
  • Bachelor's, Master's, or PhD in Chemistry, Chemical Engineering, Pharmaceutical Chemistry or other natural science
  • Requires the following, or the equivalent combination of education and experience: PhD and 4+ years, or Master's and 7+ years, or Bachelor's and 10+ years.
In this Hybrid-Eligible role, you can choose to be designated as:  Hybrid: work remotely up to two days per week; or select On-Site : work five days per week on-site with ad hoc flexibility. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com.

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locations Boston, MA time type Full time posted on Posted 6 Days Ago Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion-dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency . Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit or follow us on Facebook , Twitter/X , LinkedIn , YouTube and Instagram . The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people’s lives.  Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work. #J-18808-Ljbffr

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